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TRPV4 promotes the migration and invasion of glioma cells via AKT/Rac1 signaling

Author:
Ou-yang, Qing, Li, Bing, Xu, Minhui, Liang, Hong
Source:
Biochemical and biophysical research communications 2018 v.503 no.2 pp. 876-881
ISSN:
0006-291X
Subject:
agonists, antagonists, botulinum toxin, neoplasms, patients, phosphorylation, prognosis, therapeutics
Abstract:
Experimental evidence indicates a critical role of TRPV4 (Transient Receptor Potential Vanilloid 4) in controlling the cell migratory activity of multiple tumors. However, the oncogenic role of TRPV4 in glioma still remains elusive. In this study, we tried to investigate the oncogenic role of TRPV4 in glioma. We found that the expression levels of TRPV4 were upregulated in glioma and the high levels of TRPV4 indicated a worse prognosis in patients with glioma. TRPV4 was critical for glioma migration and invasion: activating TRPV4 by agonist GSK1016790 A enhanced glioma migration and invasion, while, the specific TRPV4 antagonist HC-067047 suppressed glioma migration and invasion. Mechanically, activated TRPV4 promoted the activation of Rac1 (Ras-related C3 botulinum toxin substrate 1) by targeting the AKT for phosphorylation, then enhanced glioma migration and invasion. All these results suggested that TRPV4 accelerates glioma migration and invasion through the AKT/Rac1 signaling, and TRPV4 might be considered as a potential target for glioma therapy.
Agid:
6128636