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Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications

Author:
Dreger, Nathan Z., Fan, Zhaobo, Zander, Zachary K., Tantisuwanno, Chinnapatch, Haines, Molly C., Waggoner, Morgan, Parsell, Trenton, Søndergaard, Claus S., Hiles, Michael, Premanandan, Christopher, Becker, Matthew L.
Source:
Biomaterials 2018 v.182 pp. 44-57
ISSN:
0142-9612
Subject:
composite films, composite polymers, extracellular matrix, fibroblasts, hernia, inflammation, mechanical properties, models, polypropylenes, rats, small intestine, synthetic products, toxicity, urea
Abstract:
The use of degradable materials is required to address current performance and functionality shortcomings from biologically-derived tissues and non-resorbable synthetic materials used for hernia mesh repair applications. Herein a series of degradable l-valine-co-l-phenylalanine poly(ester urea) (PEU) copolymers were investigated for soft-tissue repair. Poly[(1-VAL-8)0.7-co-(1-PHE-6)0.3] showed the highest uniaxial mechanical properties (332.5 ± 3.5 MPa). Additionally, l-valine-co-l-phenylalanine poly(ester urea)s were blade coated on small intestine submucosa extracellular matrix (SIS-ECM) and found to enhance the burst test mechanical properties of SIS-ECM in composite films (force at break between 102.6 ± 6.5–151.4 ± 11.3 N). Free standing films of l-valine-co-l-phenylalanine PEUs were found to have superior extension at break when compared to SIS-ECM (averages between 1.2 and 1.9 cm and 1.2 cm respectively). Fibroblast (L-929) spreading, proliferation, and improved attachment over control were observed without toxicity in vitro, while a reduced inflammatory response at both 7 and 14 days post-implant was observed for poly[(1-VAL-8)⁠0.7-co-(1-PHE-6)⁠0.3] when compared to polypropylene in an in vivo rat hernia model. These results support the use of PEU copolymers as free-standing films or as composite materials in soft-tissue applications for hernia-repair.
Agid:
6129758