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Iodine-mediated direct synthesis of multifunctional 2-aminobenzimidazoles from N-substituted o-diaminoarenes and isothiocyanates

Author:
Wang, Zhen, Zhao, Qiongli, Hou, Jiao, Yu, Wenquan, Chang, Junbiao
Source:
Tetrahedron 2018 v.74 no.19 pp. 2324-2329
ISSN:
0040-4020
Subject:
chemical structure, cycloaddition reactions, desulfurization, isothiocyanates
Abstract:
Multifunctional 2-aminobenzimidazoles were directly synthesized through sequential addition of N-substituted o-diaminoarenes to isothiocyanates, formation of carbodiimides via I2-mediated oxidative desulfurization, and intramolecular cycloaddition. This efficient and eco-friendly synthetic process provides a facile access to diverse 2-aminobenzimidazole derivatives from readily accessible substrates under mild reaction conditions in a scalable fashion.
Agid:
6130828