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Total synthesis of viscumneoside III of Viscum coloratum

Author:
Zou, Lei, Zhang, Zixue, Chen, Xiaowen, Chen, Hua, Zhang, Yi, Li, Jianqi, Liu, Yu
Source:
Tetrahedron 2018 v.74 no.19 pp. 2376-2382
ISSN:
0040-4020
Subject:
Viscum, chemical reactions, chemical structure, organic compounds
Abstract:
The first total synthesis of viscumneoside III, a promising anti-angina pectoris dihydroflavone O-glycoside isolated from Viscum coloratum was described here. Trichloroaceti-midate was employed as the apiofuranosyl donor to construct the key building block of homoeriodictyol-7-O-β-d-apiosyl-(1 → 2)-β-D-glycoside (1). The longest linear sequence (from 2 to 1) in the synthetic route required thirteen steps and afforded the final product 1 with an overall yield of 6.3%.
Agid:
6130833