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Mutagenic, antioxidant and wound healing properties of Aloe vera

Rodrigues, Luiza lucy Oliveira, de Oliveira, Ana Carolina Leal, Tabrez, Shams, Shakil, Shazi, Khan, Mohammad Imran, Asghar, Muhammad Nadeem, Matias, Bianca Dias, Batista, Joysa Michelle Alves da Silva, Rosal, Marinilva Modesto, de Lima, Marylia Maria Duarte Fulgencio, Gomes, Sávia Ribeiro Ferreira, de Carvalho, Rodrigo Mendes, de Moraes, Germano Pinho, de Alencar, Marcus Vinicius Oliveira Barros, Islam, Muhammad Torequl, Melo-Cavalcante, Ana Amélia de Carvalho
Journal of ethnopharmacology 2018 v.227 pp. 191-197
Aloe vera, Saccharomyces cerevisiae, albino, antioxidant activity, antioxidants, blood, catalase, cytotoxicity, genes, males, medicinal plants, mice, mitochondria, mutagenicity, mutagens, mutants, oxidants, sodium chloride, superoxide dismutase, traditional medicine
Aloe vera is a widely used medicinal plant for its various biological activities. This study evaluate possible mutagenic and healing effects of the aqueous extract of A. vera (AEAV) in mice and its oxidant/antioxidant potential in different proficient and deficient Saccharomyces cerevisiae strains.The AEAV was topically treated on the wounded skin surface of male albino mice at doses of 10 and 50 mg/kg for seven successive days. The control group was similarly treated with 0.9% NaCl solution. For oxidative/anti-oxidative evaluation, both proficient and deficient strains of S. cerevisiae [cytoplasmic and mitochondrial superoxide dismutase mutant (SOD: Sod1Δ and Sod2Δ), cytoplasmic catalase mutant (CAT: Cat1Δ)], two double defective mutants of Sod1 and Sod2 and Sod1 and Cat1 genes along with a wild-type strains were used.The healing property of AEAV was observed at the dose of 50 mg/kg but at the same dose it showed mutagenic and cytotoxic effects in peripheral blood. AEAV did not produce the oxidizing effect, except in the mutated CAT strain at highest concentration (50 mg/kg).The high concentration of AEAV showed mutagenicity and cytotoxicity. Beside, the healing capacity is believed to be due to its anti-oxidative defense mechanism.