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Cardioprotective role of FA against isoproterenol induced cardiac toxicity

Author:
Jain, Pankaj G., Mahajan, Umesh B., Shinde, Sachin D., Surana, Sanjay J.
Source:
Molecular biology reports 2018 v.45 no.5 pp. 1357-1365
ISSN:
0301-4851
Subject:
acute toxicity, alanine transaminase, antioxidants, aspartate transaminase, biomarkers, blood serum, body weight, cardioprotective effect, cardiotoxicity, creatinine, cytokines, drug therapy, electrocardiography, ferulic acid, glutathione, histopathology, isoproterenols, lactate dehydrogenase, malondialdehyde, nitric oxide, oxidative stress, rats, superoxide dismutase
Abstract:
The present study was designed to investigate the protective effect of ferulic acid (FA) against isoproterenol (ISO)-induced cardiac toxicity in rats. Isoproterenol challenged in a dose of 85 mg/kg body weight (b.w.) subcutaneously for two consecutive days in the experimental group resulted in acute cardiac toxicity as evidenced by changes in electrocardiogram (ECG) pattern and marked elevation of serum cardiac enzymes viz aspartate aminotransferase (AST), alanine transaminase (ALT), creatinine kinase (CK-MB) and lactate dehydrogenase (LDH) also increases inflammatory cytokines. Moreover, acute toxicity effect was exhibited by disturbance in the antioxidant system as decrease in activities of superoxide dismutase (SOD) and glutathione (GSH) with the rise in activities of malondialdehyde (MDA) and nitric oxide (NO). Pre-treatment with FA at the increasing dose of (10, 20 and 40 mg/kg b.w.) orally for 28 consecutive days followed by isoproterenol injection for 2 days significantly attenuated changes in serum cardiac enzymes. Furthermore, histopathological evaluation confirmed the restoration of cellular architecture in FA pretreated rats. The cardioprotective effect of FA was comparable with standard drug treatment metoprolol. Taken together, FA demonstrated cardioprotective effect against ISO-induced cardiac toxicity by normalization of serum cardiac biomarkers, alleviating oxidative stress and augmenting endogenous antioxidant system.
Agid:
6135191