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Ultrasonic assisted green synthesis of Fe and Fe/Zn bimetallic nanoparticles for invitro cytotoxicity study against HeLa cancer cell line

Author:
Sathya, K., Saravanathamizhan, R., Baskar, G.
Source:
Molecular biology reports 2018 v.45 no.5 pp. 1397-1404
ISSN:
0301-4851
Subject:
Coriandrum sativum, X-ray diffraction, adverse effects, antimicrobial properties, crystal structure, cytotoxicity, drug carriers, human cell lines, iron, iron oxides, leaf extracts, nanoparticles, neoplasm cells, neoplasms, reducing agents, scanning electron microscopy, ultrasonics, ultraviolet-visible spectroscopy, zinc, zinc oxide
Abstract:
Nanomaterial synthesis for the biomedical application is the latest improvement in nanotechnology. These nanomaterials can be used as therapeutic agent, drug carrier and also as activating agents. When the nanoparticles are prepared from biological sources, they show better medical competence with fewer side effects. Iron and zinc oxide nanoparticle have been found to exhibit good antimicrobial property; hence this bimetallic nanoparticle can be used for biomedical applications. Therefore the present work focused on synthesis of iron oxide and Fe/Zn bimetallic nano particle by Coriandrum sativum leaf extract as reducing agent using ultrasonic assisted method. The UV–Vis spectroscopy was used to confirm the synthesized nanoparticle. The crystallinity and shape of the particle formed was confirmed by XRD and SEM. The HeLa cell line and normal cell line were used to find the invitro cytotoxic activity of iron oxide and Fe/Zn bimetallic nanoparticle. Fe/Zn bimetallic nanoparticle and Iron oxide nanoparticle showed 61.96% and 54.95% cytotoxicity at 200 µg/ml concentration respectively against HeLa cancer cell line.
Agid:
6135198