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Investigation of pH-Sensitive Swelling and Curcumin Release Behavior of Chitglc Hydrogel
- Deka, Chayanika, Deka, Deepanwita, Bora, Montu Moni, Jha, Dhruva Kumar, Kakati, Dilip Kumar
- Journal of polymers and the environment 2018 v.26 no.10 pp. 4034-4045
- Enterobacter aerogenes, Proteus mirabilis, antibacterial properties, chitosan, curcumin, encapsulation, glucose, hydrogels, pH, reducing agents, tissue repair
- Hydrogels are in use for encapsulation of curcumin for possible use in wound healing. Encapsulation helps in targeted delivery and enhanced activity of curcumin. We report here a pH sensitive hydrogel developed from chitosan. The hydrogel was prepared by reaction of chitosan and D-glucose, facilitated by the reducing agent Na-cyanoborohydride. The maximum yield of the hydrogel was obtained at pH 4.5 with the amount of chitosan, D-glucose and Na-cyanoborohydride as 0.3, 2.0 and 2.0 g respectively. A maximum curcumin loading efficiency of 74% was observed with curcumin amount in the feed at 0.15 g. The release study revealed a sustained release pattern over a period of 80 h with an initial burst release. Curcumin loaded hydrogel showed mild antibacterial activity against Proteus mirabilis and Enterobacter aerogenes.