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Three Lycopodium alkaloids from Thai club mosses
- Nilsu, Thanasan, Thaisaeng, Wachirasak, Thamnarak, Wanlaya, Eurtivong, Chatchakorn, Jumraksa, Apiwan, Thorroad, Sakornrat, Khunnawutmanotham, Nisachon, Ruchirawat, Somsak, Thasana, Nopporn
- Phytochemistry 2018 v.156 pp. 83-88
- Huperzia, Lycopodium alkaloids, chemical constituents of plants, enzyme activity, spectroscopy
- Phytochemical constituents in alkaloid extracts from three Thai club mosses Huperzia squarrosa, Huperzia phlegmaria and Phlegmariurus nummularifolius were investigated. Squarrosinoxide was an undescribed Lycopodium alkaloid from H. squarrosa possessing an unprecedented 6/5/7 tricyclic spiro system. Acetyllycophlegmarianol was an undescribed N-oxide lycopodine-type alkaloid isolated from H. phlegmaria. 4-Epilycopodine, an undescribed epimer of lycopodine, was first isolated from P. nummularifolius. The structural assignments were established through comprehensive spectroscopic techniques and chemical correlations. All compounds were assayed for their anti-acetylcholinesterase activity in vitro.