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Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture

Author:
Nweke, Mauryn C., Rathore, Anurag S., Bracewell, Daniel G.
Source:
Trends in biotechnology 2018 v.36 no.10 pp. 992-995
ISSN:
0167-7799
Subject:
biopharmaceuticals, chromatography, manufacturing, resins
Abstract:
Poor understanding of the events leading to chromatography column aging makes it difficult to monitor column lifetimes. The lack of established procedures in this area has made it difficult to establish industry standards. Therefore, it is important to understand resin aging mechanisms and techniques to monitor column aging during operation.
Agid:
6144264