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Enterotoxigenic Escherichia coli infection promotes apoptosis in piglets

Author:
Xia, Yaoyao, Bin, Peng, Liu, Shaojuan, Chen, Shuai, Yin, Jie, Liu, Gang, Tang, Zhiyi, Ren, Wenkai
Source:
Microbial pathogenesis 2018 v.125 pp. 290-294
ISSN:
0882-4010
Subject:
apoptosis, caspase-8, caspase-9, diarrhea, enterotoxigenic Escherichia coli, humans, jejunum, pathogens, piglets
Abstract:
Enterotoxigenic Escherichia coli (ETEC), as a universal pathogen, often causes diarrhea in animals and humans. However, whether ETEC infection induces apoptosis in host remains controversial. Herein, we use ETEC-infected piglet to investigate apoptosis in the jejunum. Apoptosis and the activation of capase-3 are observed in piglet jejunum after ETEC infection. Additionally, ETEC infection induces the activation of caspase-8 pathway, but inhibits the activation of caspase-9 pathway in piglet jejunum. These findings demonstrate that ETEC infection may inhibit the intrinsic pathway and activate the extrinsic pathway of apoptosis in piglets.
Agid:
6145240