PubAg

Main content area

Inductive Coupling and Flow for Increased NMR Sensitivity

Author:
Carret, Guillaume, Berthelot, Thomas, Berthault, Patrick
Source:
Analytical chemistry 2018 v.90 no.19 pp. 11169-11173
ISSN:
1520-6882
Subject:
detection limit, equipment design, fluid mechanics, nuclear magnetic resonance spectroscopy
Abstract:
A device is proposed to enhance the NMR sensitivity of slowly relaxing nuclei, taking advantage of a controlled solution flow within a microfluidic circuit and microsized NMR detection. Unlike our previous work (Carret et al. Anal. Chem.2017, 89 (5), 2995−3000), this setup can be easily installed on any commercial NMR probehead as it uses induction between the commercial antenna and the microcoil. Such a system leads to a significant gain in sensitivity per time unit for slowly relaxing nuclei while preserving the capabilities of the host probehead.