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Nanoplastic Ingestion Enhances Toxicity of Persistent Organic Pollutants (POPs) in the Monogonont Rotifer Brachionus koreanus via Multixenobiotic Resistance (MXR) Disruption

Author:
Jeong, Chang-Bum, Kang, Hye-Min, Lee, Young Hwan, Kim, Min-Sub, Lee, Jin-Sol, Seo, Jung Soo, Wang, Minghua, Lee, Jae-Seong
Source:
Environmental science & technology 2018 v.52 no.19 pp. 11411-11418
ISSN:
1520-5851
Subject:
Brachionus, P-glycoproteins, aquatic environment, aquatic invertebrates, ingestion, lipids, microbeads, multiple drug resistance, nanoplastics, persistent organic pollutants, pollution, toxicity, triclosan
Abstract:
Among the various materials found inside microplastic pollution, nanosized microplastics are of particular concern due to difficulties in quantification and detection; moreover, they are predicted to be abundant in aquatic environments with stronger toxicity than microsized microplastics. Here, we demonstrated a stronger accumulation of nanosized microbeads in the marine rotifer Brachionus koreanus compared to microsized ones, which was associated with oxidative stress-induced damages on lipid membranes. In addition, multixenobiotic resistance conferred by P-glycoproteins and multidrug resistance proteins, as a first line of membrane defense, was inhibited by nanoplastic pre-exposure, leading to enhanced toxicity of 2,2′,4,4′-tetrabromodiphenyl ether and triclosan in B. koreanus. Our study provides a molecular mechanistic insight into the toxicity of nanosized microplastics toward aquatic invertebrates and further implies the significance of synergetic effects of microplastics with other environmental persistent organic pollutants.
Agid:
6145988