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Catenulobactins A and B, Heterocyclic Peptides from Culturing Catenuloplanes sp. with a Mycolic Acid-Containing Bacterium

Author:
Hoshino, Shotaro, Ozeki, Masahiro, Awakawa, Takayoshi, Morita, Hiroyuki, Onaka, Hiroyasu, Abe, Ikuro
Source:
Journal of natural products 2018 v.81 no.9 pp. 2106-2110
ISSN:
1520-6025
Subject:
Catenuloplanes, bacteria, coculture, cytotoxicity, gas chromatography-mass spectrometry, heterocyclic compounds, iron, isomers, mice, neoplasm cells, nuclear magnetic resonance spectroscopy, peptides
Abstract:
The production of two new heterocyclic peptide isomers, catenulobactins A (1) and B (2), in cultures of Catenuloplanes sp. RD067331 was significantly increased when it was cocultured with a mycolic acid-containing bacterium. The planar structures and absolute configurations of the catenulobactins were determined based on NMR/MS and chiral-phase GC-MS analyses. Catenulobactin B (2) displayed Fe(III)-chelating activity and moderate cytotoxicity against P388 murine leukemia cells.
Agid:
6146136