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Palladium-Catalyzed Dual C(sp²)–H Functionalization of Indole-2-carboxamides Involving a 1,2-Acyl Migration: A Synthesis of Indolo[3,2-c]quinolinones

Author:
Kong, Lingkai, Zheng, Zhong, Tang, Rong, Wang, Mengdan, Sun, Yue, Li, Yanzhong
Source:
Organic letters 2018 v.20 no.18 pp. 5696-5699
ISSN:
1523-7052
Subject:
aromatic hydrocarbons, catalytic activity, chemical reactions, copper, moieties, palladium, quinolones
Abstract:
A novel Pd/Cu catalytic system to construct indolo[3,2-c]quinolinones has been developed starting from indole-2-carboxamides. Substrates were transformed into indolo[3,2-c]quinolinones through dual C(sp²)–H functionalization of the indole moiety and arene, in which a carbonyl 1,2-migration was involved. The corresponding products were obtained in moderate to excellent yields with a wide substrate scope.
Agid:
6146550