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One for All, but Not All for One: Social Behavior during Bacterial Diseases

Author:
Davis, Kimberly M., Isberg, Ralph R.
Source:
Trends in microbiology 2019 v.27 no.1 pp. 64-74
ISSN:
0966-842X
Subject:
Mycobacterium, Salmonella, Yersinia, antibiotic resistance, genes, metabolism, pathogenesis, proteins, virulence
Abstract:
It has been known for decades that individual cells within pathogenic bacterial populations have reduced antibiotic susceptibility, which is linked to decreased metabolic rates. A similar phenomenon occurs with virulence-associated proteins, as reduced expression is associated with increased fitness of individual cells. Non-producers within the population can benefit from the virulence proteins produced by others in the population without suffering a fitness cost, thus maintaining a genetically uniform population. Cooperative behavior has been reported for Salmonella and Yersinia, consistent with selection of social behavior to retain genes associated with pathogenesis; however, cooperation was unclear within Mycobacterium populations. This review focuses on these recent descriptions of cooperation, discusses the mechanisms driving heterogeneity, and evaluates the evidence that expression of virulence-associated proteins comes at a fitness cost.
Agid:
6147598