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Hypoglycemic and hypolipidemic effects of samnamul (shoot of Aruncus dioicus var. kamtschaticus Hara) in mice fed a high-fat/high-sucrose diet

Author:
Kim, Jung-In, Yun, Jeong-A, Jeong, Yoo-Kyung, Baek, Hee-Jin
Source:
Food science and biotechnology 2018 v.27 no.5 pp. 1467-1473
ISSN:
1226-7708
Subject:
Aruncus dioicus, acarbose, alpha-glucosidase, animal models, blood glucose, cholesterol, diet, enzyme activity, enzyme inhibition, glucose, glycemic effect, homeostasis, hyperglycemia, hyperlipidemia, insulin resistance, lipemic effect, mice, noninsulin-dependent diabetes mellitus, oral administration, small intestine, sucrose alpha-glucosidase, triacylglycerols
Abstract:
The hypoglycemic and hypolipidemic effects of samnamul were investigated. The α-glucosidase inhibitory activity of samnamul in vivo was determined in normal mice. Oral administration of samnamul extract (500 mg/kg) or acarbose (50 mg/kg) significantly reduced the postprandial glucose response. The effects of chronic consumption of samnamul on fasting hyperglycemia and dyslipidemia were determined in C57BL/6 J mice with diabetes mellitus induced by a high-fat/high-sucrose (HFHS) diet. Consumption of samnamul extract at 0.5% of the diet for 12 weeks decreased serum glucose, triglyceride, and cholesterol levels, the homeostasis model assessment for insulin resistance index, and activities of maltase and sucrase in the small intestine. These results suggest that samnamul had hypoglycemic and hypolipidemic effects in an animal model of type 2 diabetes and that the hypoglycemic effect occurred partly via the inhibition of α-glucosidase activity.
Agid:
6151290