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Forsskamide, a new ceramide from aerial parts of Forsskaolea tenacissima Linn.

Author:
Assaf, Hamdy K., Nafady, Alaa M., Allam, Ahmed E., Hamed, Ashraf N. E., Kamel, Mohamed S., Shimizu, Kuniyoshi
Source:
Natural product research 2018 v.32 no.20 pp. 2452-2456
ISSN:
1478-6427
Subject:
Urticaceae, aerial parts, ceramides, chemical composition, chemical structure, colorectal neoplasms, cytotoxicity, fluorouracil, human cell lines, inhibitory concentration 50, neoplasm cells, nuclear magnetic resonance spectroscopy, traditional medicine
Abstract:
Although the various folk medicine uses and the biological activity of Forsskaolea tenacissima L., few chemical constituents of this plant have been reported, this provoked us to make our study. Forsskamide, a new ceramide was isolated from aerial parts of F. tenacissima L. (Urticaceae). The chemical structure was established by different spectroscopic methods (¹H, ¹³C-NMR, HMBC, HSQC, ROESY, FAB-MS and HR-FAB-MS). Forsskamide showed a moderate cytotoxic activity by (MTT) method against human colorectal carcinoma cell line (HCT-116) with IC₅₀ 33.25 μM in comparison with 5-fluorouracil IC₅₀ 26.42 μM. While, it did not show any activity against human hepatocarcinaoma cell line (HepG-2).
Agid:
6152975