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Novel mastadenovirus infection and clinical disease in a pygmy marmoset (Callithrix [Cebuella] pygmaea)

Author:
Gál, János, Hornyák, Ákos, Mándoki, Míra, Bakonyi, Tamás, Balka, Gyula, Szeredi, Levente, Marosán, Miklós, Ludányi, Tibor, Forgách, Petra, Sós, Endre, Demeter, Zoltán, Farkas, Szilvia L.
Source:
Veterinary microbiology 2013 v.167 no.3-4 pp. 695-699
ISSN:
0378-1135
Subject:
Callithrix, Canine adenovirus A, Chiroptera, Equine adenovirus A, bronchopneumonia, dogs, epithelial cells, genes, giant cells, hyperplasia, virus transmission
Abstract:
We describe the detection and successful isolation of a novel mastadenovirus from a pygmy marmoset (Callithrix [Cebuella] pygmaea) that died following an episode of severe respiratory signs. Pathologic/histopathologic examination revealed hydrothorax and catarrhal bronchopneumonia with pronounced desquamation of the bronchiolar epithelial cells, while in other airways a marked hyperplasia of the epithelial lining and numerous giant cells could be observed. We obtained partial sequence data from the adenoviral DNA-dependent DNA-polymerase gene of the isolated strain and analyses of this region showed the highest level of identity to the recently described bat adenoviruses (strains PPV1 and TJM) and the type 2 canine adenovirus. Similar results were gained by phylogenetic calculations indicating that this novel marmoset adenovirus is only distantly related to reference Old and New World primate adenoviruses and formed a monophyletic group with bat and canine adenoviruses and the equine adenovirus 1. Even though the source of the infection remained unknown, our results could imply the possibility of a cross-species transmission of the virus from an anonymous host to the pygmy marmoset.
Agid:
615411