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Selenium nanocomposites as multifunctional nanoplatform for imaging guiding synergistic chemo-photothermal therapy

Author:
Liu, Xijian, Wang, Yeying, Yu, Qiyang, Deng, Guoying, Wang, Qian, Ma, Xinhui, Wang, Qiugen, Lu, Jie
Source:
Colloids and surfaces 2018 v.166 pp. 161-169
ISSN:
0927-7765
Subject:
colloids, fluorescence, image analysis, nanocomposites, neoplasms, photochemotherapy, selenium
Abstract:
A multifunctional selenium nanocomposite (selenium@silica core-shell nanoshperes for loading indocyanine green(ICG)/Doxorubicin(DOX)) was fabricated to reach visible and efficient cancer treatment. The Se@SiO2-ICG nanocomposites could be used not only as excellent photothermal agents but also as carriers for DOX delivery. In addition, the Se@SiO2-ICG/DOX nanocomposites exhibited excellent fluorescence imaging and infrared imaging performance. Tumor could be effectively inhibited by Se@SiO2-ICG/DOX due to the triple treatment of photothermal effect and chemotherapy of selenium and DOX. Thus, the Se@SiO2-ICG/DOX nanocomposites have a great potential in imaging guiding synergistic treatment of cancer.
Agid:
6157182