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LncRNA FAL1 promotes carcinogenesis by regulation of miR-637/NUPR1 pathway in colorectal cancer

Author:
Wang, Liqiang, Jiang, Fuquan, Xia, Xiaopu, Zhang, Bin
Source:
The international journal of biochemistry & cell biology 2019 v.106 pp. 46-56
ISSN:
1357-2725
Subject:
carcinogenesis, colorectal neoplasms, therapeutics, tissues
Abstract:
LncRNA FAL1 has been demonstrated to play an important role in promoting carcinogenesis via the ceRNA mechanism in several types of cancer. However, the role and the mechanism of lncRNA FAL1 in CRC remain unclear. Here our results demonstrate that lncRNA FAL1 is markedly upregulated in CRC tissues and cells, and lncRNA FAL1 promotes proliferation ability, migration and invasion in CRC cells. Additionally, we demonstrate that lncRNA FAL1 acts as a sponge of miR-637, which functions as a suppressor via targeting and downregulation of NUPR1 expression. Moreover, we demonstrate that lncRNA FAL1 promotes carcinogenesis of CRC cells via regulation of the miR-637/NUPR1 pathway. Taken together, our findings underscore the crucial roles of lncRNA FAL1 in CRC carcinogenesis and its potential prognostic and therapeutic value.
Agid:
6157770