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Phytochemical constituents and cytotoxic activity of Physalis angulata L. growing in Vietnam

Author:
Tuan Anh, Hoang Le, Thao, Do Thi, Dung, Duong Thi, Kiem, Phan Van, Quang, Tran Hong, Hai Yen, Pham Thi, Tuan, Do Thanh, Cuong, Pham Viet, Viet Cuong, Le Canh, Hung, Tran Manh
Source:
Phytochemistry letters 2018 v.27 pp. 193-196
ISSN:
1874-3900
Subject:
Physalis angulata, cell lines, chemical constituents of plants, chemical structure, cytotoxicity, inhibitory concentration 50, metabolites, neoplasm cells, nuclear magnetic resonance spectroscopy, Vietnam
Abstract:
A comprehensive phytochemical investigation of the dichloromethane-soluble fraction of Physalis angulata led to the isolation of eight compounds (1–8) including two new withanolides named physagulin P and Q (compounds 5 and 8). Their chemical structures were established using two-dimensional nuclear magnetic resonance (spectroscopy. The cytotoxic activity of these metabolites was investigated against A549, HeLa, and PANC-1 cancer cell lines. Among them, compound 1 showed significant cytotoxic activity against A549 cells with a half-maximal inhibitory concentration (IC50) value of 8.27 μM, while compound 7 showed the most potent activity against PANC-1 cells with an IC50 value of 3.18 μM.
Agid:
6158033