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Lipidomics biomarker studies: Errors, limitations, and the future

Author:
Wood, Paul L., Cebak, John E.
Source:
Biochemical and biophysical research communications 2018 v.504 no.3 pp. 569-575
ISSN:
0006-291X
Subject:
biomarkers, lipid peroxidation, lipids, metabolomics, surveys
Abstract:
Lipidomics is an ever-expanding subfield of metabolomics that surveys 3000 to 5000 individual lipids across more than 56 lipid subclasses, including lipid peroxidation products. Unfortunately, there exists a large number of publications with poor quality data obtained with unit mass resolution leading to many lipid misidentifications. This is further complicated by poor scientific oversight with regard to recognition of isobar issues, sample collection, and sample storage issues that inexplicably requires more detailed attention. Inadvertent or intentional obfuscation of relative quantification data represented as absolute quantification is a subtle but profound difference that may readers outside of the field may not realize, therefore, instigating disservice and unnecessary distrust in the scientific community. These issues need to be addressed aggressively as high quality data are essential for the translation of biomarker research to clinical practice.
Agid:
6159169