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Dynamics of alternative polyadenylation in human preimplantation embryos

Author:
Chang, Jen-Yun, Yu, Wen-Hsuan, Juan, Hsueh-Fen, Huang, Hsuan-Cheng
Source:
Biochemical and biophysical research communications 2018 v.504 no.4 pp. 727-733
ISSN:
0006-291X
Subject:
early development, embryogenesis, gene expression, humans, microRNA, neoplasm cells, neoplasms
Abstract:
Alternative polyadenylation (APA) affects the length of the 3′ untranslated region (3′-UTR) and the regulation of microRNAs. Previous studies have shown that cancer cells tend to have shorter 3′-UTRs than normal cells. A plausible explanation for this is that it enables cancer cells to escape the regulation of microRNAs. Here, we extend this concept to an opposing context: changes in 3′-UTR length in the development of the human preimplantation embryo. Unlike cancer cells, during early development 3′-UTRs tended to become longer, and gene expression was negatively correlated with 3′-UTR length. Moreover, our functional enrichment results showed that length changes are part of the development mechanism. We also investigated the analogy of 3′-UTR length variation with respect to lncRNAs and found that, similarly, lncRNA length tended to increase during embryo development.
Agid:
6159204