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Sort Your Self Out!
- Uggenti, Carolina, Crow, Yanick J.
- Cell 2018 v.172 no.4 pp. 640-642
- gain-of-function mutation, immunity, nucleic acids, retrotransposons
- Discrimination between viral and self-derived nucleic acid species is crucial in maintaining effective antiviral immunity whilst avoiding autoinflammation. Ahmad et al. and Chung et al. delineate the consequences of MDA5 gain of function and loss of ADAR1 activity, highlighting the blurring of the concept of self and non-self when considering endogenous retroelements.