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A review on injectable chitosan/beta glycerophosphate hydrogels for bone tissue regeneration

Author:
Saravanan, Sekaran, Vimalraj, Selvaraj, Thanikaivelan, Palanisamy, Banudevi, Sivanantham, Manivasagam, Geetha
Source:
International journal of biological macromolecules 2019 v.121 pp. 38-54
ISSN:
0141-8130
Subject:
additives, bioactive compounds, bones, cell growth, chitosan, extracellular matrix, gelation, hydrogels, thermosensitivity, tissue engineering, tissue repair
Abstract:
Tissue engineering (TE) is a promising approach for repairing diseased and damaged bone tissue. Injectable hydrogel based strategies offer a wide range of applications in rapid recovery of bone defects by acting as filler materials and depots for delivering various bioactive molecules and averting the need for surgical intervention. Chitosan (CS), a natural polysaccharide, forms a thermosensitive injectable hydrogel through the addition of beta-glycerophosphate (β-GP). This hybrid hydrogel possesses numerous advantages namely mimicking native extracellular matrix (ECM) and providing an amenable microenvironment for cell growth. In this review, a brief insight into the gelation mechanism of CS/GP hydrogels, modifications, bioactive additives and their applications in treating bone defects are presented.
Agid:
6159990