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Solidification of liquid Modified Apple Polysaccharide by its adsorption on solid porous carriers through spray drying and evaluation of its potential as binding agent for tablets

Author:
Mohanta, Souvik, Singh, Sachin Kumar, Kumar, Bimlesh, Gulati, Monica, Jyoti, Jivan, Som, Sananda, Panchal, Sakshi, Melkani, Indu, Banerjee, Mayukh, Sinha, Shubham Kumar, Khursheed, Rubiya, Yadav, Ankit Kumar, Verma, Vishu, Kumar, Rajan, Sharma, Deep Shikha, Malik, Adil Hussain, Pandey, Narendra Kumar, Wadhwa, Sheetu
Source:
International journal of biological macromolecules 2018 v.120 pp. 1975-1998
ISSN:
0141-8130
Subject:
Fourier transform infrared spectroscopy, adsorption, apples, binding agents, differential scanning calorimetry, granules, hardness, liquids, polysaccharides, polyvinylpyrrolidone, scanning electron microscopy, solidification, spray drying, trehalose
Abstract:
In the present study application of Modified Apple Polysaccharide (MAP) as tablet binder was evaluated. Liquid MAP was extracted from apple and solidified by adsorbing it on porous surface of Aerosil-200 and trehalose and this dispersion was dried using spray dryer. The concentration of excipients as well as spray drying conditions was optimised by using Box Behnken Design to achieve desirable powder characteristics. The optimised batch of solid MAP was characterized by DSC, PXRD, SEM, and FT-IR studies that confirmed complete adsorption of liquid MAP on the surface of Aerosil-200 and trehalose. This solid MAP was investigated for its binding efficacy for tablet formulation and its binding potential was compared with acacia and polyvinyl pyrrolidone K-30. Mesalamine (model drug) granules containing different concentration of binders were prepared by wet granulation. The granules were evaluated for micromeritic properties and results were found within the pharmacopoeial limits. The prepared tablets were subjected for post compression studies such as hardness, friability, disintegration, dissolution, physical stability, content uniformity and percentage elastic recovery and their results were found good. At 2.5% w/w concentration in tablet, the solid MAP has shown shorter disintegration time and faster dissolution profile as compared to other concentrations used including good physico-mechanical properties.
Agid:
6159998