PubAg

Main content area

A new polyoxygenated abietane diterpenoid from the rattans of Bauhinia championii (Benth.) Benth

Author:
Hua, Li-Ping, Zhang, Yu-Qin, Ye, Miao, Xu, Wen, Wang, Xiao-Ying, Fu, Yan-Hui, Xu, Wei
Source:
Natural product research 2018 v.32 no.21 pp. 2577-2582
ISSN:
1478-6427
Subject:
Bauhinia, Calamus, arthritis, diterpenoids, inhibitory concentration 50, methotrexate, spectroscopy
Abstract:
A new polyoxygenated abietane diterpenoid, bauchampine A (1), together with seven known compounds (2–8), were isolated from the rattans of Bauhinia championii (Benth.) Benth. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with the data reported in the literature. New compound 1 was evaluated for its anti-rheumatoid arthritis activity via examining its anti-proliferative effect on synoviocytes in vitro. Compound 1 exhibited inhibitory effect on the proliferation of synoviocytes with IC₅₀ value comparable to that of methotrexate.
Agid:
6162160