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Antimicrobial susceptibility and molecular typing of toxigenic clinical isolates of Clostridium difficile causing infections in the south of Spain

Author:
Arca-Suárez, J., Galán-Sánchez, F., Cano-Cano, F., García-Santos, G., Rodríguez-Iglesias, M.A.
Source:
Anaerobe 2018 v.54 pp. 146-150
ISSN:
1075-9964
Subject:
Clostridium difficile, amino acids, anti-infective agents, antibiotic resistance, drugs, hospitals, molecular genetics, moxifloxacin, patients, Spain
Abstract:
Antimicrobial susceptibility to 6 antimicrobial agents, PCR-ribotyping and molecular genetics of fluoroquinolone resistance was assessed in 70 toxigenic clinical isolates of C. difficile recovered from patients attended in a hospital in southern Spain with suspected Clostridium difficile infection. Moxifloxacin was the least active drug, mainly driven by the aminoacid substitution Thr82Ile in GyrA, while PCR-ribotype 078 was the most prevalent lineage identified and grouped several of the fluoroquinolone resistant isolates.
Agid:
6162737