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Legionella quorum sensing and its role in pathogen–host interactions

Author:
Personnic, Nicolas, Striednig, Bianca, Hilbi, Hubert
Source:
Current opinion in microbiology 2018 v.41 pp. 29-35
ISSN:
1369-5274
Subject:
Legionella pneumophila, bacteria, genes, host-pathogen relationships, pathogens, pneumonia, quorum sensing, secondary infection, virulence
Abstract:
Legionella pneumophila is a water-borne opportunistic pathogen causing a life-threatening pneumonia called ‘Legionnaires’ disease’. The Legionella quorum sensing (Lqs) system produces and responds to the α-hydroxyketone signaling molecule 3-hydroxypentadecane-4-one (Legionella autoinducer-1, LAI-1). The Lqs system controls the switch between the replicative/non-virulent and the transmissive/virulent phase of L. pneumophila, and it is a major regulator of natural competence, motility and virulence of the pathogen. Yet, beyond gene regulation, LAI-1 also directly affects pathogen–host interactions, since the signaling molecule modulates the migration of eukaryotic cells. Genes encoding Lqs homologues are present in many environmental bacteria, suggesting that α-hydroxyketone signaling is widely used for inter-bacterial as well as inter-kingdom signaling. In this review we summarize recent advances on the characterization of the Lqs system and its role in L. pneumophila–host cell interactions.
Agid:
6162873