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Effects of dietary selenium on host response to necrotic enteritis in young broilers

Xu, Shouzhen, Lee, Sung-Hyen, Lillehoj, Hyun S., Hong, Yeong Ho, Bravo, David
Research in veterinary science 2015 v.98 pp. 66
Clostridium perfringens, Eimeria maxima, antibodies, body weight, broiler chickens, coccidiosis, dietary supplements, digestive system, excretion, feces, inducible nitric oxide synthase, interleukin-1beta, interleukin-6, interleukin-8, lesions (animal), messenger RNA, necrotic enteritis, oocysts, selenium, spleen
The effects of dietary supplementation of young broiler chickens with an organic selenium (Se) formulation, B-Traxim Se, on experimental necrotic enteritis (NE) were studied. Chickens treated with three Se doses (0.25, 0.50, 1.00 mg/kg) from hatch were orally challenged with Eimeria maxima at 14 days of age followed by Clostridium perfringens to induce NE. Chickens fed with 0.50 mg/kg Se showed significantly increased body weights and antibody levels against NetB, and significantly reduced gut lesions compared with non-supplemented chickens. However, there were no significant differences in Eimeria oocyst shedding between the Se-treated and non-supplemented groups. Levels of IL-1β, IL-6, IL-8, iNOS, LITAF, TNFSF15, AvBD6, AvBD8, and AvBD13 transcripts were increased in the gut and spleen of at least one of the three Se-treated groups compared with the non-treated group. These results suggest that dietary supplementation of young broilers with Se might be beneficial to reduce the negative consequence of NE.