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Fast and reliable generation of [¹⁸F]triflyl fluoride, a gaseous [¹⁸F]fluoride source

Author:
Pees, A., Sewing, C., Vosjan, M. J. W. D., Tadino, V., Herscheid, J. D. M., Windhorst, A. D., Vugts, D. J.
Source:
Chemical communications 2018 v.54 no.72 pp. 10179-10182
ISSN:
1364-548X
Subject:
ambient temperature, chemical reactions, distillation, drying, fluorides, models, organofluorine compounds, solvents, superoxide anion, tracer techniques
Abstract:
A novel strategy for the production of reactive [¹⁸F]fluoride has been developed, omitting time consuming azeotropic drying procedures. Gaseous [¹⁸F]triflyl fluoride is formed instantaneously at room temperature from hydrated [¹⁸F]fluoride, followed by distillation in less than 5 minutes into a dry aprotic solvent, in which dry [¹⁸F]fluoride is released in presence of base with >90% radiochemical yield. The reactivity of the [¹⁸F]fluoride has been confirmed by reaction with several model compounds and by the synthesis of the PET tracers [¹⁸F]fluoroestradiol ([¹⁸F]FES) and O-2-[¹⁸F]fluoroethyl-l-tyrosine ([¹⁸F]FET), providing good isolated radiochemical yields and molar activities of up to 123 GBq μmol⁻¹.
Agid:
6166273