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An active DNA-based nanoprobe for photoacoustic pH imaging
- BaumannThese authors contributed equally., Kevin N., Fux, Alexandra C., Joseph, James, Bohndiek, Sarah E., Hernández-Ainsa, Silvia
- Chemical communications 2018 v.54 no.72 pp. 10176-10178
- DNA, chemical reactions, image analysis, neoplasms, pH, sodium
- We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a promising platform to probe pH values relevant to the tumor microenvironment using PA.