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An active DNA-based nanoprobe for photoacoustic pH imaging

Author:
BaumannThese authors contributed equally., Kevin N., Fux, Alexandra C., Joseph, James, Bohndiek, Sarah E., Hernández-Ainsa, Silvia
Source:
Chemical communications 2018 v.54 no.72 pp. 10176-10178
ISSN:
1364-548X
Subject:
DNA, chemical reactions, image analysis, neoplasms, pH, sodium
Abstract:
We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a promising platform to probe pH values relevant to the tumor microenvironment using PA.
Agid:
6166293