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Topology- and linking number-controlled synthesis of a closed 3 link chain of single-stranded DNA

Author:
Li, Qi, Wu, Guangqi, Yang, Yanyan, An, Ran, Li, Jing, Liang, Xingguo, Komiyama, Makoto
Source:
Chemical communications 2018 v.54 no.72 pp. 10156-10159
ISSN:
1364-548X
Subject:
chemical compounds, chemical reactions, hybridization, isomers, oligonucleotides, single-stranded DNA, topology
Abstract:
In spite of remarkable progress in synthetic methodology, a closed three-link chain (one of the simplest but the most important topological isomers of [3]catenane) has never been prepared. Here we synthesized this isomer in high yield from three oligonucleotides which are designed to optimize various chemical and steric factors in their mutual hybridization.
Agid:
6166335