Jump to Main Content
Topology- and linking number-controlled synthesis of a closed 3 link chain of single-stranded DNA
- Li, Qi, Wu, Guangqi, Yang, Yanyan, An, Ran, Li, Jing, Liang, Xingguo, Komiyama, Makoto
- Chemical communications 2018 v.54 no.72 pp. 10156-10159
- chemical compounds, chemical reactions, hybridization, isomers, oligonucleotides, single-stranded DNA, topology
- In spite of remarkable progress in synthetic methodology, a closed three-link chain (one of the simplest but the most important topological isomers of catenane) has never been prepared. Here we synthesized this isomer in high yield from three oligonucleotides which are designed to optimize various chemical and steric factors in their mutual hybridization.