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Reductive cyclisations of amidines involving aminal radicals

Author:
Huang, Huan-Ming, Adams, Ralph W., Procter, David J.
Source:
Chemical communications 2018 v.54 no.72 pp. 10160-10163
ISSN:
1364-548X
Subject:
alkenes, amidines, cyclization reactions, electron transfer, free radicals
Abstract:
Amidines bearing simple alkenes undergo aminal radical cyclisation upon treatment with SmI₂. The mild, reductive electron transfer process delivers medicinally-relevant, polycyclic quinazolinone derivatives in good to excellent yield and typically with complete diastereocontrol.
Agid:
6166345