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Exploring the intramolecular catalysis of the proton exchange process to modulate the relaxivity of Gd(iii)-complexes of HP-DO3A-like ligands
- Carnovale, Irene Maria, Lolli, Marco Lucio, Serra, Sonia Colombo, Mingo, Alberto Fringuello, Napolitano, Roberta, Boi, Valeria, Guidolin, Nicol, Lattuada, Luciano, Tedoldi, Fabio, Baranyai, Zsolt, Aime, Silvio
- Chemical communications 2018 v.54 no.72 pp. 10056-10059
- catalytic activity, chemical reactions, gadolinium, hydrogen bonding, ligands, moieties, molybdenum, phenol
- The Gd(iii)-complexes of three novel HP-DO3A-like ligands have been investigated to assess the relationship between relaxometry and intramolecular catalysis of the proton exchange. The structures of these ligands differ from the parent HP-DO3A because the methyl group of the hydroxy-propyl arm has been replaced by –Ph–OH, –Ph–NH₂ and –Ph–COOH, respectively. The phenol, amine and carboxylate functionalities display an intramolecular H-bonding with the coordinated hydroxyl moiety that affects either the pK values of the involved functionalities and the rate of the proton exchange process.