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Anti-inflammatory and Proapoptotic Properties of the Natural Compound o-Orsellinaldehyde

Tomas-Hernandez, Sarah, Garcia-Vallvé, Santiago, Pujadas, Gerard, Valls, Cristina, Ojeda-Montes, María José, Gimeno, Aleix, Cereto-Massagué, Adrià, Roca-Martinez, Joel, Suárez, Manuel, Arola, Lluis, Blanco, Jordi, Mulero, Miquel, Beltran-Debón, Raúl
Journal of agricultural and food chemistry 2018 v.66 no.42 pp. 10952-10963
Grifola frondosa, apoptosis, cardiovascular diseases, databases, enzymes, forests, humans, inflammation, metabolic syndrome, mushrooms, noninsulin-dependent diabetes mellitus, risk, transcription factors
Metabolic syndrome is a cluster of medical conditions that increases the risk of developing cardiovascular disease and type 2 diabetes. Numerous studies have shown that inflammation is directly involved in the onset of metabolic syndrome and related pathologies. In this study, in silico techniques were applied to a natural products database containing molecules isolated from mushrooms from the Catalan forests to predict molecules that can act as human nuclear-factor κβ kinase 2 (IKK-2) inhibitors. IKK-2 is the main component responsible for activating the nuclear-factor κβ transcription factor (NF-κβ). One of these predicted molecules was o-orsellinaldehyde, a molecule present in the mushroom Grifola frondosa. This study shows that o-orsellinaldehyde presents anti-inflammatory and pro-apoptotic properties by acting as IKK-2 inhibitor. Additionally, we suggest that the anti-inflammatory and pro-apoptotic properties of Grifola frondosa mushroom could partially be explained by the presence of o-orsellinaldehyde on its composition.