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A novel pyrazolo[1,5-a]pyridine fluorophore and its application to detect pH in cells

Author:
Zhang, Ping, Lv, Huaying, Duan, Guiyun, Dong, Jian, Ge, Yanqing
Source:
RSC advances 2018 v.8 no.54 pp. 30732-30735
ISSN:
2046-2069
Subject:
fluorescent dyes, pH, pyridines
Abstract:
A new fluorescent probe based on pyrazolo[1,5-a]pyridine was synthesized and used to monitor the pH in cells. This probe exhibited a fast response to acidic pH (less than 10 s), a high quantum yield (φ = 0.64), and high selectivity and sensitivity. The response mechanism of the fluorescent probes relies on the ICT change.
Agid:
6171771