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A biomimetic fluorescent chemosensor for highly sensitive zinc(ii) detection and its application for cell imaging
- Yan, Rui, Wang, Zhi, Du, Zongliang, Wang, Haibo, Cheng, Xu, Xiong, Junjie
- RSC advances 2018 v.8 no.58 pp. 33361-33367
- aqueous solutions, biocompatibility, biomimetics, composite polymers, cytotoxicity, fluorescence, image analysis, metal ions, phosphorylcholine, polymerization, zinc
- To fabricate a novel biomimetic fluorescent chemosensor, PSaAEMA-co-PMPC was synthesized via atom transfer radical polymerization, and this copolymer could be used for the detection of zinc(ii) and cell imaging. A series tests with various metal ions verified the specific fluorescence response behavior. This novel biomimetic fluorescent chemosensor exhibits excellent selectivity for Zn²⁺ ions over a wide range of tested metal ions in an aqueous solution. Moreover, cytotoxicity and bio-imaging tests were conducted to study the potential bio-application of the chemosensor. Owing to the biomimetic portion (phosphorylcholine), this copolymer possesses outstanding biocompatibility and could clearly image cells. The results indicated that PSaAEMA-co-PMPC has great potential for application in zinc(ii) detection and cell imaging.