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Cobalt(iii)-catalyzed site-selective C–H amidation of pyridones and isoquinolones

Author:
Gao, Feng, Han, Xu, Li, Chunpu, Liu, Lingjun, Cong, Zhanqing, Liu, Hong
Source:
RSC advances 2018 v.8 no.57 pp. 32659-32663
ISSN:
2046-2069
Subject:
catalysts, catalytic activity, cobalt, pyridones, quinolones
Abstract:
In this study, Cp*Co(iii)-catalyzed site-selective amidation of pyridones and isoquinolones using oxazolones as the amidation reagent is reported. This approach features mild conditions, high efficiency and good functional tolerance. Furthermore, gram-scale preparation and preliminary mechanism experiments were carried out. It provides a straightforward approach for the direct modification of pyridone derivatives.
Agid:
6171863