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Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy

Author:
LiuThese authors contributed equally to this work., Lin, Wang, Ruibo, Wang, Chunran, Wang, Jinze, Chen, Li, Cheng, Jianjun
Source:
Biomaterials science 2018 v.6 no.5 pp. 997-1001
ISSN:
2047-4849
Subject:
drugs, nanocarriers, neoplasms, photochemotherapy
Abstract:
Herein, we present a series of light-triggered porphyrin-based polymeric drug conjugates PSDTD-m for combined chemo-photodynamic therapy of cancer. The controlled release of a drug through a ROS-cleavable linker combined with photodynamic therapy showed enhanced anticancer efficacy, proving the effectiveness of this light triggered smart nanocarrier platform for enhancing the therapy efficacy.
Agid:
6173352