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A highly fluorescent water soluble spirobifluorene dye with a large Stokes shift: synthesis, characterization and bio-applications
- Schlüter, Friederike, Riehemann, Kristina, Kehr, Nermin Seda, Quici, Silvio, Daniliuc, Constantin G., Rizzo, Fabio
- Chemical communications 2018 v.54 no.6 pp. 642-645
- biocompatibility, chemical compounds, chemical reactions, color, cytotoxicity, detection limit, dyes, fluorescence, image analysis, proteins, water solubility
- The first water-soluble spirobifluorene derivative has been synthesized, which exhibits high fluorescence quantum yield and a large Stokes shift (>100 nm). Proteins induce changes in the emission color, allowing to reach the nanomolar detection limit. Cellular uptake and cytotoxicity studies in living cells revealed its biocompatibility, indicating potential application for live cell imaging.