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A highly fluorescent water soluble spirobifluorene dye with a large Stokes shift: synthesis, characterization and bio-applications

Author:
Schlüter, Friederike, Riehemann, Kristina, Kehr, Nermin Seda, Quici, Silvio, Daniliuc, Constantin G., Rizzo, Fabio
Source:
Chemical communications 2018 v.54 no.6 pp. 642-645
ISSN:
1364-548X
Subject:
biocompatibility, chemical compounds, chemical reactions, color, cytotoxicity, detection limit, dyes, fluorescence, image analysis, proteins, water solubility
Abstract:
The first water-soluble spirobifluorene derivative has been synthesized, which exhibits high fluorescence quantum yield and a large Stokes shift (>100 nm). Proteins induce changes in the emission color, allowing to reach the nanomolar detection limit. Cellular uptake and cytotoxicity studies in living cells revealed its biocompatibility, indicating potential application for live cell imaging.
Agid:
6174221