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Copper/guanidine-catalyzed asymmetric alkynylation of isatin-derived ketimines
- Chen, Quangang, Xie, Lihua, Li, Zhaojing, Tang, Yu, Zhao, Peng, Lin, Lili, Feng, Xiaoming, Liu, Xiaohua
- Chemical communications 2018 v.54 no.6 pp. 678-681
- chemical reactions, copper, enantioselectivity, guanidines, ketimines
- Isatin-derived ketimines undergo enantioselective alkynylation reactions in the presence of copper iodide and easily accessible guanidine-amides. The corresponding 3-alkynyl-3-aminooxyindoles are obtained in up to 95% yield and 96% ee. The guanidine plays a role in the formation of copper acetylide and the enantiodetermining step and the basic additive is excluded.