PubAg

Main content area

Copper/guanidine-catalyzed asymmetric alkynylation of isatin-derived ketimines

Author:
Chen, Quangang, Xie, Lihua, Li, Zhaojing, Tang, Yu, Zhao, Peng, Lin, Lili, Feng, Xiaoming, Liu, Xiaohua
Source:
Chemical communications 2018 v.54 no.6 pp. 678-681
ISSN:
1364-548X
Subject:
chemical reactions, copper, enantioselectivity, guanidines, ketimines
Abstract:
Isatin-derived ketimines undergo enantioselective alkynylation reactions in the presence of copper iodide and easily accessible guanidine-amides. The corresponding 3-alkynyl-3-aminooxyindoles are obtained in up to 95% yield and 96% ee. The guanidine plays a role in the formation of copper acetylide and the enantiodetermining step and the basic additive is excluded.
Agid:
6174252