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An access to 1,3-azasiline-fused quinolinones via oxidative heteroannulation involving silyl C(sp³)–H functionalization
- WuThese authors contributed equally to this work., Li-Jun, Yang, Yuan, Song, Ren-Jie, Yu, Jiang-Xi, Li, Jin-Heng, He, De-Liang
- Chemical communications 2018 v.54 no.11 pp. 1367-1370
- chemical reactions, cleavage (chemistry), drugs, quinolones, silanes, silicon
- A Mn-promoted intermolecular oxidative radical heteroannulation of N-(2-cyanoaryl)-acrylamides and tertiary silanes has been described, which provides an efficient route to produce silicon/nitrogen heterocycles, sila-analogues of the known carbon-based structural motifs prevalent in bioactive natural products, pharmaceuticals and materials. The reaction enables Si-incorporation by controlling accurately several chemical bond cleavage and formation processes. Moreover, this reaction represents a new one-step construction of 1,3-azasiline-fused quinolinones that was achieved via silyl C(sp³)–H functionalization using an oxidative radical strategy.