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Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

Author:
Chu, Xue-Qiang, Cheng, Bu-Qing, Zhang, Yao-Wei, Ge, Danhua, Shen, Zhi-Liang, Loh, Teck-Peng
Source:
Chemical communications 2018 v.54 no.21 pp. 2615-2618
ISSN:
1364-548X
Subject:
amidines, organic halogen compounds, oxidation, pyrimidines
Abstract:
An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C–C/C–N bonds and a new six-membered ring through a radical addition/oxidation/cyclization sequence in a one-pot manner.
Agid:
6174427