PubAg

Main content area

A benzoic acid terpyridine-based cyclometalated iridium(iii) complex as a two-photon fluorescence probe for imaging nuclear histidine

Author:
ZhangThese authors contributed equally to this work., Qiong, Lu, Xin, Wang, Hui, Tian, Xiaohe, Wang, Aidong, Zhou, Hongping, Wu, Jieying, Tian, Yupeng
Source:
Chemical communications 2018 v.54 no.30 pp. 3771-3774
ISSN:
1364-548X
Subject:
benzoic acid, chemical reactions, fluorescent dyes, histidine, image analysis, iridium, microscopy
Abstract:
A series of two-photon active cyclometalated iridium(iii) complexes (Ir1, Ir2 and Ir3) were designed. Ir1 with a two-photon action cross-section of 40 GM in the NIR region has been developed for targeting intracellular histidine. Two-photon micrographs showed that Ir1 could rapidly and selectively light up the nucleus in both fixed and live cells and is capable of displaying nuclear histidine distribution in ultra-detail using a super resolution (SR) technique under stimulated emission depletion (STED) microscopy.
Agid:
6174776