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Manganese catalyzed reductive amination of aldehydes using hydrogen as a reductant

Author:
Wei, Duo, Bruneau-Voisine, Antoine, Valyaev, Dmitry A., Lugan, Noël, Sortais, Jean-Baptiste
Source:
Chemical communications 2018 v.54 no.34 pp. 4302-4305
ISSN:
1364-548X
Subject:
aldehydes, alkylation, amination, amines, amino alcohols, catalysts, hydrogen, imines, manganese, reducing agents
Abstract:
A one-pot two-step procedure was developed for the alkylation of amines via reductive amination of aldehydes using molecular dihydrogen as a reductant in the presence of a manganese pyridinyl-phosphine complex as a pre-catalyst. After the initial condensation step, the reduction of imines formed in situ is performed under mild conditions (50–100 °C) with 2 mol% of catalyst and 5 mol% of tBuOK under 50 bar of hydrogen. Excellent yields (>90%) were obtained for a large combination of aldehydes and amines (40 examples), including aliphatic aldehydes and amino-alcohols.
Agid:
6175009