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An MTH1-targeted nanosystem for enhanced PDT via improving cellular sensitivity to reactive oxygen species
- FanThese authors contributed equally to this work., Huanhuan, Zhang, Lili, Hu, Xiaoxiao, Zhao, Zilong, Bai, Huarong, Fu, Xiaoyi, Yan, Guobei, Liang, Li-Hui, Zhang, Xiao-Bing, Tan, Weihong
- Chemical communications 2018 v.54 no.34 pp. 4310-4313
- chemical compounds, chemical reactions, nanotechnology, neoplasm cells, photochemotherapy, reactive oxygen species, small interfering RNA
- Herein, we developed a strategy to attack the cancer cell defense system against reactive oxygen species to improve photodynamic therapy efficacy with a Ce6@MSN@MTH1 siRNA nanosystem, which was demonstrated to improve cellular sensitivity to reactive oxygen species through suppressing MTH1 protein in cancer cells.