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Efficient peptide ligation between allyl-protected Asp and Cys followed by palladium-mediated deprotection

Author:
Kamo, Naoki, Hayashi, Gosuke, Okamoto, Akimitsu
Source:
Chemical communications 2018 v.54 no.34 pp. 4337-4340
ISSN:
1364-548X
Subject:
aspartic acid, chemical reactions, cysteine, moieties, palladium, peptides, protein synthesis
Abstract:
An efficient method for peptide ligation between C-terminal Asp(OAllyl) and N-terminal Cys has been developed. Peptide ligation and removal of the allyl group at the Asp carboxylate side chain proceeded in one pot by adding a small amount of Pd/TPPTS complex. Based on this efficient synthetic method, PEP-19 (61 amino acids), which is highly expressed in Purkinje cells, was synthesized.
Agid:
6175043