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Optochemical control of gene expression by photocaged guanine and riboswitches
- Dhamodharan, V., Nomura, Yoko, Dwidar, Mohammed, Yokobayashi, Yohei
- Chemical communications 2018 v.54 no.48 pp. 6181-6183
- Escherichia coli, RNA, chemical reactions, gene expression, guanine, mammals, proteins
- Optical control of biomolecules via engineered proteins or photoactive small molecules has had a profound impact on biology. However, optochemical tools to control RNA functions in living cells are relatively limited. We synthesized a photoactivatable (photocaged) guanine to modulate gene expression under riboswitch control in both mammalian cells and Escherichia coli by light.