PubAg

Main content area

Optochemical control of gene expression by photocaged guanine and riboswitches

Author:
Dhamodharan, V., Nomura, Yoko, Dwidar, Mohammed, Yokobayashi, Yohei
Source:
Chemical communications 2018 v.54 no.48 pp. 6181-6183
ISSN:
1364-548X
Subject:
Escherichia coli, RNA, chemical reactions, gene expression, guanine, mammals, proteins
Abstract:
Optical control of biomolecules via engineered proteins or photoactive small molecules has had a profound impact on biology. However, optochemical tools to control RNA functions in living cells are relatively limited. We synthesized a photoactivatable (photocaged) guanine to modulate gene expression under riboswitch control in both mammalian cells and Escherichia coli by light.
Agid:
6175121